POSITIVE: CNTRP Paediatric Outcomes in Transplant: Personalising Immunosuppression to Improve Efficacy
Principal Investigator: Dr. Patricia Birk
Adequate control of immunosuppression is essential to prevent graft failure after transplantation and to avoid life-threatening viral and malignant complications. Children undergo periods of rapid change from birth to young adulthood as their bodies change with growth and maturation- this makes achieving optimal immunosuppression in children difficult.
Knowledge gained from the POSITIVE study will help to tailor post-transplant management to the unique needs of growing children and young adults with the goal of prolonging graft survival, delaying re-transplantation and ultimately improving the long-term quality of life of patients post transplant.
This includes how post-transplant immunosuppression can be adjusted to meet the unique needs of child, reduce the risk of developing viral and malignant complications, and way to improve adherence with medicines after transplant.