DREAM Seminar Series + Trainee Pizza Lunch
Friday, March 6th, Dr. Jennifer Estall from Université de Montréal will be presenting “Dissecting the Hepatic Fasting Response and how this helps to understand MASLD” in A207 Chown Building and Zoom from 12 – 1 p.m.
Following the presentation there will be a trainee pizza lunch in 501E JBRC from 1 – 2 p.m. Please RSVP to the calendar invite no later than March 4th, 2026, along with any dietary restrictions to Rushie Tyagi (tyagir@myumanitoba.ca).
Bio
Dr. Jennifer Estall is known for her work on transcriptional regulators in nutrient metabolism and diabetes pathogenesis. She received her Ph.D. from the University of Toronto and post-doctoral training at Harvard Medical School, where she was awarded the H.L. Holmes Award from the National Research Council of Canada for her work in diabetes. She is currently a Full Research Professor at the Institut de recherches clinique de Montréal (IRCM), holding academic affiliations to the University of Montreal and McGill University. Her research focuses on nutrient metabolism linked to cell survival, mechanisms of metabolic disease and related cancer, and how mitochondrial dysfunction impacts diabetes and steatotic liver disease through organ crosstalk. Honours include a CIHR New Investigator Award, FRQS Chercheurs-boursiers and the Diabetes Canada Young Scientist Award.
Talk Info
The liver orchestrates an intricate transition between fasting and feeding states. Interestingly, fasting is not purely catabolic; instead, it represents a metabolic condition in which opposing anabolic and catabolic pathways operate in parallel, involving proper coordination of many pathways functioning in harmony. Failure to maintain the delicate switch between these biological processes impairs energy balance and contributes to the pathogenesis of metabolic disorders. We aim to understand the roles and regulation of transcriptional regulators involved in the hepatic fasting response, in both physiological and pathological contexts. In this talk, we will explore a new pathway that controls the rapid and dynamic shift between anabolic and catabolic states during fasting/re-feeding. I will take you through how we found that PGC-1α and its transcriptional partners coordinate the fasting response and how this may impact the development of MASLD.
Zoom Link
https://umanitoba.zoom.us/j/68978544741?pwd=7aVOPVRdJXrlKXICf3BLq8uRYnecGr.1
Meeting ID
689 7854 4741
Passcode
782086