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X-WR-CALDESC:Events for Children’s Hospital Research Institute of Manitoba
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DTSTART;TZID=America/Winnipeg:20251106T080000
DTEND;TZID=America/Winnipeg:20251106T090000
DTSTAMP:20260411T050043
CREATED:20250805T143552Z
LAST-MODIFIED:20251103T173059Z
UID:11923-1762416000-1762419600@www.chrim.ca
SUMMARY:Pediatric Grand Rounds
DESCRIPTION:Speaker\nDr. Sharoon Qaiser\, MD\nDepartment of Child Neurology\, Kentucky Neurosciences Institute\, University of Kentucky \nTopic\nA Headache Story \nObjectives\n\nDescribe the non-headache symptoms of migraine\nExplain the relationship between periodic disorders and headaches in children\nDescribe the importance of past medical history in diagnosing current medical condition\n\nTime\n8:00 AM – 9:00 AM \nLocation\nVirtual \nhttps://umanitoba.zoom.us/j/69337719459?pwd=bGqivnmXKYAN0dY6I4TlZDd3uhnIhI.1 \nMeeting ID: 693 3771 9459\nPasscode: 493458
URL:https://www.chrim.ca/event/pediatric-grand-rounds-40/
CATEGORIES:University of Manitoba
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Winnipeg:20251113T080000
DTEND;TZID=America/Winnipeg:20251113T090000
DTSTAMP:20260411T050043
CREATED:20250805T143713Z
LAST-MODIFIED:20251103T173641Z
UID:11925-1763020800-1763024400@www.chrim.ca
SUMMARY:Pediatric Grand Rounds
DESCRIPTION:Speaker\nDr. Lindsay Crowshoe\, MD\nAssociate Professor\, Department of Family Medicine\, Cummings School Of Medicine\, University of Calgary \nTopic\nDREAM Symposium (Dr. Heather Dean Lectureship)\nSocial and Cultural Mechanisms of a Relational Approach to Diabetes Care with Indigenous Patients \nTime\n8:00 AM – 9:00 AM \nLocation\nHybrid. In-person location Samuel N. Cohen Auditorium (SBGH) \nhttps://umanitoba.zoom.us/j/69337719459?pwd=bGqivnmXKYAN0dY6I4TlZDd3uhnIhI.1 \nMeeting ID: 693 3771 9459\nPasscode: 493458
URL:https://www.chrim.ca/event/pediatric-grand-rounds-41/
CATEGORIES:University of Manitoba
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Winnipeg:20251120T080000
DTEND;TZID=America/Winnipeg:20251120T090000
DTSTAMP:20260411T050043
CREATED:20250805T143809Z
LAST-MODIFIED:20251103T173947Z
UID:11927-1763625600-1763629200@www.chrim.ca
SUMMARY:Pediatric Grand Rounds
DESCRIPTION:Speaker\nDr. Irene Lara-Corrales\, MD\, MSc\nProfessor of Pediatrics\, University of Toronto\, Pediatric Dermatologist\, Hospital for Sick Children \nTopic\nDr. Arthur Birt Lectureship: Lessons Learned in a Café-au-lait Screening Clinic \nObjectives \n\nPresent lessons learned in a Café-au-lait screening clinic\nReview my approach to patients with multiple CALMs\nDiscuss disorders that mimic CALMs\, different genetic disorders than can present with CALMs\, and more\n\nTime\n8:00 AM – 9:00 AM \nLocation\nVirtual \nhttps://umanitoba.zoom.us/j/69337719459?pwd=bGqivnmXKYAN0dY6I4TlZDd3uhnIhI.1 \nMeeting ID: 693 3771 9459\nPasscode: 493458
URL:https://www.chrim.ca/event/pediatric-grand-rounds-42/
CATEGORIES:University of Manitoba
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Winnipeg:20251126T090000
DTEND;TZID=America/Winnipeg:20251126T100000
DTSTAMP:20260411T050043
CREATED:20251118T181940Z
LAST-MODIFIED:20251118T181940Z
UID:12320-1764147600-1764151200@www.chrim.ca
SUMMARY:Preimplantation Alcohol Exposure: Lasting Epigenomic\, Transcriptomic and Brain Effects
DESCRIPTION:Speaker\nDr. Serge McGraw\nDept. of Obstetrics and Gynecology in the Azrieli Research Center\, Université de Montréal \nTopic\nPreimplantation Alcohol Exposure: Lasting Epigenomic\, Transcriptomic and Brain Effects\nPrenatal alcohol exposure (PAE) can shape long-term health and cause Fetal Alcohol Spectrum Disorder (FASD). The effects of PAE during the preimplantation period are poorly understood. Using a mouse model with a single binge-like exposure at the 8-cell stage (E2.5)\, we investigated consequences for brain and placental development. \nEarly exposure produced growth delays and brain malformations\, with widespread DNA methylation and transcriptomic changes in the embryonic forebrain. Key neurodevelopmental genes\, including Arx\, Dlx2\, Lhx6 and Sox6\, were dysregulated\, correlating with delayed migration of GABAergic interneurons and long-term behavioral deficits.  Analyses of late-gestation placentas revealed epigenetic and transcriptional dysregulation in genes involved in growth regulation and serotonin transport. Using machine learning\, placental DNA methylation profiles accurately distinguished alcohol-exposed embryos from controls. \nTogether\, these results reveal early epigenetic origins of FASD and thus support placental methylation signatures as a molecular tool for detecting prenatal alcohol exposure at birth and improving early diagnosis. \nLearning Objectives\nBy the end of this session\, participants will be able to: \n\nExplain how alcohol exposure during the preimplantation period impacts early embryonic and brain development.\nDiscuss how early preimplantation alcohol exposure results in lasting epigenetic and transcriptomic alterations during brain development.\nConnect these altered epigenetic and transcriptomic changes to abnormal GABAergic migration and behavioral outcomes.\n\nDetails\nNovember 26\, 2025\n9:00 AM in BMSB341
URL:https://www.chrim.ca/event/preimplantation-alcohol-exposure-lasting-epigenomic-transcriptomic-and-brain-effects/
LOCATION:341\, BMSB
CATEGORIES:University of Manitoba
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Winnipeg:20251127T080000
DTEND;TZID=America/Winnipeg:20251127T090000
DTSTAMP:20260411T050043
CREATED:20250805T143843Z
LAST-MODIFIED:20251124T152414Z
UID:11929-1764230400-1764234000@www.chrim.ca
SUMMARY:Pediatric Grand Rounds
DESCRIPTION:Speaker\nDr. Anna Shawyer\, MSc\, MD\, FRCSC\nAssistant Professor\, Department of Surgery\, Rady Faculty of Health Sciences\, University of Manitoba \nTopic\nUltra-marathons & Pediatric Surgery & Team Building \nObjectives\nDiscuss the links between ultra-marathoning\, pediatric surgery through the topics of Commitment\, Collaboration\, Controversy\, Community\, Compassion \nTime\n8:00 AM – 9:00 AM \nLocation\nVirtual \nhttps://umanitoba.zoom.us/j/66989557873?pwd=iwtwQ9CMv0moCfi2grbjqub9kFUURe.1 \nMeeting ID: 669 8955 7873\nPasscode: 744304
URL:https://www.chrim.ca/event/pediatric-grand-rounds-43/
CATEGORIES:University of Manitoba
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